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Article

Coronavirus S protein alters dsRNA accumulation and stress granule formation through regulation of ADAR1-p150 expression.

Nucleic acids research - 27 Nov 2024

Fan Baochao, Li Yupeng, Wang Yi, Yang Shanshan, Peng Qi, Qian Jiali, Wang Chuanhong, Zhang Xue, Xu Hong, Liu Shiyu, He Wenlong, Zhang Gege, Zhu Xuejiao, Li Yunchuan, Zhao Yongxiang, Hu Mi, Wang Wei, Zhou Jinzhu, Guo Rongli, He Kongwang, Li Bin

Abstract excerpt

The precise role of the highly variable coronavirus S protein in modulating innate immune responses remains unclear. In this study, we demonstrated that the mutant strain of swine coronavirus porcine enteric diarrhea virus induced significantly lower levels of double-stranded RNA (dsRNA) accumulation, inhibited protein kinase R (PKR) activation and suppressed stress granule (SG) formation compared with the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39445805
DOI: 10.1093/nar/gkae921
PMCID: PMC11602127

Genes

TCF7L2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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