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Viral evasion of PKR restriction by reprogramming cellular stress granules

11 Jul 2022

Abstract excerpt

Protein kinase R (PKR) is a critical host restriction factor against invading viral pathogens. However, this molecule is inactivated in the cells infected with porcine reproductive and respiratory syndrome virus (PRRSV), an economically devastating pathogen to the world swine industry. Here, we report that this event is to suppress cellular inflammation and is mediated by the viral replicase protein nsp1β. We...

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PMID: 35858300
DOI: 10.1073/pnas.2201169119

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