The etiology of glomerulonephritis: roles of infection and autoimmunity.

Abstract excerpt

Despite major advances in understanding genetic predispositions ('first hits'), pathogenic immune responses, and the mediators of tissue injury in glomerulonephritis (GN), there remains a dearth of knowledge about the etiologic events, or 'second hits', which trigger these diseases. This paper reviews evidence that infections initiate most forms of GN through numerous simultaneous and/or sequential pathways that...

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