Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Combining highly multiplexed PCR with semiconductor-based sequencing for rapid cancer genotyping.

The Journal of molecular diagnostics : JMD - 1 Mar 2013

Beadling Carol, Neff Tanaya L, Heinrich Michael C, Rhodes Katherine, Thornton Michael, Leamon John, Andersen Mark, Corless Christopher L

Abstract excerpt

There is growing demand for routine identification of actionable mutations in clinical cancer specimens. Genotyping platforms must provide rapid turnaround times and work effectively with limited amounts of formalin-fixed, paraffin-embedded (FFPE) tissue specimens that often yield poor quality DN...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Library
Share to Genetic Variation
Share to Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotyping Techniques

Share to Multiplex Polymerase Chain Reaction

Share to Neoplasms

Share to ROC Curve

Share to Sequence Analysis, DNA

Source

Identifiers

PMID: 23274167
DOI: 10.1016/j.jmoldx.2012.09.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23274167-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Combining highly multiplexed PCR with semiconductor-based sequencing for rapid cancer genotyping.PMID 23274167Read ↗

Versatile ion S5XL sequencer for targeted next generation sequencing of solid tumors in a clinical laboratory.Semantic proximity Read ↗

Quantitative assessment of mutant allele burden in solid tumors by semiconductor-based next-generation sequencing.Semantic proximity Read ↗

Optimizing an ion semiconductor sequencing data analysis method to identify somatic mutations in the genomes of cancer cells in clinical tissue samples.Semantic proximity Read ↗

Clinical Validation and Implementation of a Targeted Next-Generation Sequencing Assay to Detect Somatic Variants in Non-Small Cell Lung, Melanoma, and Gastrointestinal Malignancies.Semantic proximity Read ↗

Rapid targeted somatic mutation analysis of solid tumors in routine clinical diagnostics.Semantic proximity Read ↗

Genotyping of Frequent Mutations in Solid Tumors by PCR-Based Single-Base Extension and MassARRAY Analysis.Semantic proximity Read ↗

Clinical validation of a next-generation sequencing screen for mutational hotspots in 46 cancer-related genes.Semantic proximity Read ↗

Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT): A Hybridization Capture-Based Next-Generation Sequencing Clinical Assay for Solid Tumor Molecular Oncology.Semantic proximity Read ↗

Accurate Detection of Multiple Tumor Mutations in Formalin-Fixed Paraffin-Embedded Tissues by Coupling Sequence Artifacts Elimination and Mutation Enrichment With MeltArray.Semantic proximity Read ↗

Single-copy detection of somatic variants from solid and liquid biopsy.Semantic proximity Read ↗

Validation and Application of a Custom-Designed Targeted Next-Generation Sequencing Panel for the Diagnostic Mutational Profiling of Solid Tumors.Semantic proximity Read ↗

Development and validation of a whole-exome sequencing test for simultaneous detection of point mutations, indels and copy-number alterations for precision cancer careSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.