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Article

Estimation of the mutation rate of Mycobacterium tuberculosis in cases with recurrent tuberculosis using whole genome sequencing.

Scientific reports - 6 Oct 2022

Comín Jessica, Cebollada Alberto, Samper Sofía

Abstract excerpt

The study of tuberculosis latency is problematic due to the difficulty of isolating the bacteria in the dormancy state. Despite this, several in vivo approaches have been taken to mimic the latency process. Our group has studied the evolution of the bacteria in 18 cases of recurrent tuberculosis. We found that HIV positive patients develop recurrent tuberculosis earlier, generally in the first two years (p...

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Identifiers

PMID: 36202945
DOI: 10.1038/s41598-022-21144-0
PMCID: PMC9537313

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