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Article

Experimental Evolution of Mycobacterium tuberculosis in Human Macrophages Results in Low-Frequency Mutations Not Associated with Selective Advantage.

PloS one - 1 Jan 2016

Guerrini Valentina, Subbian Selvakumar, Santucci Pierre, Canaan Stéphane, Gennaro Maria Laura, Pozzi Gianni

Abstract excerpt

Isolates of the human pathogen Mycobacterium tuberculosis recovered from clinical samples exhibit genetic heterogeneity. Such variation may result from the stressful environment encountered by the pathogen inside the macrophage, which is the host cell tubercle bacilli parasitize. To study the evolution of the M. tuberculosis genome during growth inside macrophages, we developed a model of intracellular culture in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred BALB C

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Source

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Identifiers

PMID: 27959952
DOI: 10.1371/journal.pone.0167989
PMCID: PMC5154527

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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