Article
Higher genome mutation rates of Beijing lineage of Mycobacterium tuberculosis during human infection.
Scientific reports - 22 Oct 2020
Hakamata Mariko, Takihara Hayato, Iwamoto Tomotada, Tamaru Aki, Hashimoto Atsushi, Tanaka Takahiro, Kaboso Shaban A, Gebretsadik Gebremichal, Ilinov Aleksandr, Yokoyama Akira, Ozeki Yuriko, Nishiyama Akihito, Tateishi Yoshitaka, Moro Hiroshi, Kikuchi Toshiaki, Okuda Shujiro, Matsumoto Sohkichi
Abstract excerpt
Mycobacterium tuberculosis (Mtb) strains of Beijing lineage have caused great concern because of their rapid emergence of drug resistance and worldwide spread. DNA mutation rates that reflect evolutional adaptation to host responses and the appearance of drug resistance have not been elucidated in human-infected Beijing strains. We tracked and obtained an original Mtb isolate of Beijing lineage from the 1999...
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