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Article

Nullifying the CDKN2AB Locus Promotes Mutant K-ras Lung Tumorigenesis

12 Mar 2014

Abstract excerpt

UNLABELLED: Lung cancer commonly displays a number of recurrent genetic abnormalities, and about 30% of lung adenocarcinomas carry activating mutations in the Kras gene, often concomitantly with inactivation of tumor suppressor genes p16(INK4A) and p14(ARF) of the CDKN2AB locus. However, little is known regarding the function of p15INK4B translated from the same locus. To determine the frequency of CDKN2AB loss...

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PMID: 24618618
DOI: 10.1158/1541-7786.mcr-13-0620-t

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