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Article

A novel receptor-induced activation site in the Nipah virus attachment glycoprotein (G) involved in triggering the fusion glycoprotein (F).

The Journal of biological chemistry - 16 Jan 2009

Aguilar Hector C, Ataman Zeynep Akyol, Aspericueta Vanessa, Fang Angela Q, Stroud Matthew, Negrete Oscar A, Kammerer Richard A, Lee Benhur

Abstract excerpt

Cellular entry of paramyxoviruses requires the coordinated action of both the attachment (G/H/HN) and fusion (F) glycoproteins, but how receptor binding activates G to trigger F-mediated fusion during viral entry is not known. Here, we identify a receptor (ephrinB2)-induced allosteric activation site in Nipah virus (NiV) G involved in triggering F-mediated fusion. We first generated a conformational monoclonal...

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Identifiers

PMID: 19019819
DOI: 10.1074/jbc.M807469200
PMCID: PMC2615506

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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