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Article

Synthetic promoters for CHO cell engineering

25 Feb 2014

Abstract excerpt

We describe for the first time the creation of a library of 140 synthetic promoters specifically designed to regulate the expression of recombinant genes in CHO cells. Initially, 10 common viral promoter sequences known to be active in CHO cells were analyzed using bioinformatic sequence analysis programs to determine the identity and relative abundance of transcription factor regulatory elements (TFREs; or...

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PMID: 24615264
DOI: 10.1002/bit.25227

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