An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1.

doi:10.1172/JCI73441

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Article

An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1.

The Journal of clinical investigation - 1 Apr 2014

Bonsignori Mattia, Wiehe Kevin, Grimm Sebastian K, Lynch Rebecca, Yang Guang, Kozink Daniel M, Perrin Florence, Cooper Abby J, Hwang Kwan-Ki, Chen Xi, Liu Mengfei, McKee Krisha, Parks Robert J, Eudailey Joshua, Wang Minyue, Clowse Megan, Criscione-Schreiber Lisa G, Moody M Anthony, Ackerman Margaret E, Boyd Scott D, Gao Feng, Kelsoe Garnett, Verkoczy Laurent, Tomaras Georgia D, Liao Hua-Xin, Kepler Thomas B, Montefiori David C, Mascola John R, Haynes Barton F

Abstract excerpt

Broadly HIV-1-neutralizing antibodies (BnAbs) display one or more unusual traits, including a long heavy chain complementarity-determining region 3 (HCDR3), polyreactivity, and high levels of somatic mutations. These shared characteristics suggest that BnAb development might be limited by immune tolerance controls. It has been postulated that HIV-1-infected individuals with autoimmune disease and defective immune...

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Identifiers

PMID: 24614107
DOI: 10.1172/JCI73441
PMCID: PMC3973118

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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