Article
Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated.
The Journal of experimental medicine - 24 Oct 2011
Liao Hua-Xin, Chen Xi, Munshaw Supriya, Zhang Ruijun, Marshall Dawn J, Vandergrift Nathan, Whitesides John F, Lu Xiaozhi, Yu Jae-Sung, Hwang Kwan-Ki, Gao Feng, Markowitz Martin, Heath Sonya L, Bar Katharine J, Goepfert Paul A, Montefiori David C, Shaw George C, Alam S Munir, Margolis David M, Denny Thomas N, Boyd Scott D, Marshal Eleanor, Egholm Michael, Simen Birgitte B, Hanczaruk Bozena, Fire Andrew Z, Voss Gerald, Kelsoe Garnett, Tomaras Georgia D, Moody M Anthony, Kepler Thomas B, Haynes Barton F
Abstract excerpt
The initial antibody response to HIV-1 is targeted to envelope (Env) gp41, and is nonneutralizing and ineffective in controlling viremia. To understand the origins and characteristics of gp41-binding antibodies produced shortly after HIV-1 transmission, we isolated and studied gp41-reactive plasma cells from subjects acutely infected with HIV-1. The frequencies of somatic mutations were relatively high in these...
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