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Article

Interacting effect of BDNF Val66Met polymorphism and stressful life events on adolescent depression.

Genes, brain, and behavior - 1 Nov 2012

Chen J, Li X, McGue M

Abstract excerpt

There is a strong etiological link between brain-derived neurotrophic factor and depression, but the neurocellular mechanisms and gene-environment interactions remain obscure. This study investigated whether one functional polymorphism in the brain-derived neurotrophic factor gene (BDNF Val66Met) modulates the influence of stressful life events on adolescent depressive symptoms. A total of 780 pairs of ethnic Han...

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Identifiers

PMID: 22931410
DOI: 10.1111/j.1601-183X.2012.00843.x

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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