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5-HTTLPR and BDNF Val66Met polymorphisms moderate effects of stress on rumination

11 Jul 2011

Abstract excerpt

This study examined whether polymorphisms in the serotonin transporter (SLC6A4, 5-HTTLPR) and brain-derived neurotropic factor (BDNF Val66Met, rs6265) genes moderate the relationship between life stress and rumination. Participants were a large homogenous group of healthy, unmedicated, never depressed individuals with few current symptoms of depression (N = 273). Results indicate that individuals with two short...

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PMID: 21745335
DOI: 10.1111/j.1601-183x.2011.00715.x

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