Analysis of 10,478 cancer genomes identifies candidate driver genes and opportunities for precision oncology.

Abstract excerpt

Tumor genomic profiling is increasingly seen as a prerequisite to guide the treatment of patients with cancer. To explore the value of whole-genome sequencing (WGS) in broadening the scope of cancers potentially amenable to a precision therapy, we analysed whole-genome sequencing data on 10,478 patients spanning 35 cancer types recruited to the UK 100,000 Genomes Project. We identified 330 candidate driver genes,...

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• Genome, Human
• Genomics
• Medical Oncology
• Mutation
• Neoplasms