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Article

Genetic Architecture of Trans-Laminar Cribrosa Pressure Difference and Primary Open-Angle Glaucoma.

Investigative ophthalmology & visual science - 1 Apr 2026

Hong In-Shik, Cho Chamlee, Kim Beomsu, Shim Injeong, Lee Yeong Chan, Jung Sang-Hyuk, Song Minku, Park Sanghyeon, Hong Sanghoon, Jo Hyeonbin, Kim Hoyoung, Seo Je Hyun, Won Hong-Hee

Abstract excerpt

Purpose: The purpose of this study was to investigate whether the genetic architecture of translaminar cribrosa pressure difference (TLCPD) provides genetic insights based on dual-pressure theory beyond intraocular pressure (IOP) and whether a TLCPD-based polygenic risk score (PRS) predicts primary open-angle glaucoma (POAG) risk and its pleiotropic effects. Methods: The genome-wide association study (GWAS) of...

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Identifiers

PMID: 42017308
DOI: 10.1167/iovs.67.4.51
PMCID: PMC13107994

Genes

FBXO46
JUND
NUPR1
PILRB
SDCCAG8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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