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Article

Exploring the Shared Genetic Architectures Between Primary Open-Angle Glaucoma and Visual Pathway Regions in the Brain.

Investigative ophthalmology & visual science - 1 Dec 2025

Aman Asma M, MacGregor Stuart, Diaz-Torres Santiago, Gharahkhani Puya

Abstract excerpt

Purpose: To investigate the genetic relationships between primary open-angle glaucoma (POAG) and major visual pathways in the brain to better understand the neurological biology of glaucoma, which may facilitate the discovery of neuroprotective drug targets. Methods: We assessed the relationship between POAG and the volumes of five visual pathway regions using genetic correlation and polygenic risk score (PRS)....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41328997
DOI: 10.1167/iovs.66.15.11
PMCID: PMC12697700

Genes

EEF1AKMT2
MAPKAPK5
PHETA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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