Article
The first steps of adaptation of Escherichia coli to the gut are dominated by soft sweeps.
PLoS genetics - 1 Mar 2014
Barroso-Batista João, Sousa Ana, Lourenço Marta, Bergman Marie-Louise, Sobral Daniel, Demengeot Jocelyne, Xavier Karina B, Gordo Isabel
Abstract excerpt
The accumulation of adaptive mutations is essential for survival in novel environments. However, in clonal populations with a high mutational supply, the power of natural selection is expected to be limited. This is due to clonal interference--the competition of clones carrying different beneficial mutations--which leads to the loss of many small effect mutations and fixation of large effect ones. If interference...
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