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Article

Characterizing variability in warfarin dose requirements in children using modelling and simulation.

British journal of clinical pharmacology - 1 Jul 2014

Hamberg Anna-Karin, Wadelius Mia, Friberg Lena E, Biss Tina T, Kamali Farhad, Jonsson E Niclas

Abstract excerpt

AIMS: Although genetic, clinical and demographic factors have been shown to explain approximately half of the inter-individual variability in warfarin dose requirement in adults, less is known about causes of dose variability in children. This study aimed to identify and quantify major genetic, clinical and demographic sources of warfarin dose variability in children using modelling and simulation. METHODS:...

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Source

Open in PubMed Open full text

Identifiers

PMID: 24330000
DOI: 10.1111/bcp.12308
PMCID: PMC4168390

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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