MYC proteins promote neuronal differentiation by controlling the mode of progenitor cell division.

doi:10.1002/embr.201337424

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Article

MYC proteins promote neuronal differentiation by controlling the mode of progenitor cell division.

EMBO reports - 1 Apr 2014

Zinin Nikolay, Adameyko Igor, Wilhelm Margareta, Fritz Nicolas, Uhlén Per, Ernfors Patrik, Henriksson Marie Arsenian

Abstract excerpt

The role of MYC proteins in somatic stem and progenitor cells during development is poorly understood. We have taken advantage of a chick in vivo model to examine their role in progenitor cells of the developing neural tube. Our results show that depletion of endogenous MYC in radial glial precursors (RGPs) is incompatible with differentiation and conversely, that overexpression of MYC induces neurogenesis...

Topics

Animals
Avian Proteins
Cell Differentiation
Cell Division
Cell Proliferation
Cells, Cultured
Chick Embryo
Chickens
Ependymoglial Cells
Gene Expression
Neural Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neural Tube

Neurogenesis

Oncogene Protein p55(v-myc)

Phenotype

Proto-Oncogene Proteins c-myc

Receptors, Notch

Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 24599748
DOI: 10.1002/embr.201337424
PMCID: PMC3989669

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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