Enhanced expression of MycN/CIP2A drives neural crest toward a neural stem cell-like fate: Implications for priming of neuroblastoma

Abstract excerpt

Significance Neuroblastoma is a neural crest-derived pediatric cancer that develops in the embryonic peripheral nervous system (PNS). Studies of PNS progenitors have failed to uncover how tumors initiate or fully recapitulate the most aggressive forms of the disease. Previous transcriptome analysis reveals similarity between some neuroblastoma samples and neural stem cells. Here, we show that ectopic expression...

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