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Article

Genetic drivers of etiologic heterogeneity in thyroid cancer.

Nature communications - 10 Jul 2026

Jee Yon Ho, Pozdeyev Nikita, Gignoux Christopher R, White Samantha, Haugen Bryan R, Verma Anurag, Peculis Raitis, Rovite Vita, Mulford Ashley J, Sanders Alan R, Kitahara Cari M, Reeve Mary Pat, Kraft Peter, Martin Alicia R

Abstract excerpt

Thyroid cancer is the most common endocrine malignancy, yet its biological underpinnings remain incompletely understood. Here we show that common risk alleles for thyroid cancer point to distinct biological pathways underlying disease susceptibility. We perform a multi-ancestry genome-wide association meta-analysis of thyroid cancer (16,167 cases and 2,430,374 controls), identifying 51 independent loci, including...

Topics

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CHEK2 gene
TERT gene
Genetic Heterogeneity
Genetic Predisposition to Disease
Genetic Risk Score

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genome-Wide Association Study

Polymorphism, Single Nucleotide

Thyroid Neoplasms

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Open in PubMed Open full text

Identifiers

PMID: 42431967
DOI: 10.1038/s41467-026-75111-8
PMCID: PMC13483233

Genes

ATM
CHEK2
TERT
TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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