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Sox2 Is Required to Maintain Cancer Stem Cells in a Mouse Model of High-Grade Oligodendroglioma

5 Mar 2014

Abstract excerpt

The stem cell-determining transcription factor Sox2 is required for the maintenance of normal neural stem cells. In this study, we investigated the requirement for Sox2 in neural cancer stem-like cells using a conditional genetic deletion mutant in a mouse model of platelet-derived growth factor-induced malignant oligodendroglioma. Transplanting wild-type oligodendroglioma cells into the brain generated lethal...

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PMID: 24599129
DOI: 10.1158/0008-5472.can-13-1942

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Sox2 Is Required to Maintain Cancer Stem Cells in a Mouse Model of High-Grade OligodendrogliomaPMID 24599129Read ↗

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Sox2 protein stability is enhanced by BRafV600E and Pten deletion in adult neural stem/progenitor cellsSemantic proximity Read ↗

A SOX2-engineered epigenetic silencer factor represses the glioblastoma genetic program and restrains tumor developmentSemantic proximity Read ↗

Combination of a Ptgs2 Inhibitor and an Epidermal Growth Factor Receptor-Signaling Inhibitor Prevents Tumorigenesis of Oligodendrocyte Lineage-Derived Glioma-Initiating CellsSemantic proximity Read ↗

Mir-21–Sox2 Axis Delineates Glioblastoma Subtypes with Prognostic ImpactSemantic proximity Read ↗

Genetic and epigenetic modifications of Sox2 contribute to the invasive phenotype of malignant gliomas.Semantic proximity Read ↗

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