Article

Sox2 protein stability is enhanced by BRafV600E and Pten deletion in adult neural stem/progenitor cells

2026-03-12

Abstract excerpt

<title>Abstract</title> <p>BRAF mutations are oncogenic drivers present in about 7% of human cancers, with the V600E substitution being the most frequent. In the nervous system, BRAFV600E has been identified in both low- and high-grade gliomas (LGG and HGG) and in tumors of the peripheral nervous system. To investigate the mechanisms underlying BRafV600E-driven tumorigenesis, we generated a mouse model in which t...

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Literature Corpus work: 4b624cf0-c1bd-517c-ab0d-935a535c16cb
DOI: 10.21203/rs.3.rs-7515762/v1

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