Article
Building bridges toward invasion: tumor promoter treatment induces a novel protein kinase C-dependent phenotype in MCF10A mammary cell acini.
PloS one - 1 Jan 2014
Klos Kristine S, Warmka Janel K, Drachenberg Disa M, Chang Liang, Luxton G W Gant, Leung Cheuk T, Schwertfeger Kathryn L, Wattenberg Elizabeth V
Abstract excerpt
The potent tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) alters many cellular processes through activation of its receptor protein kinase C (PKC), including gene expression, cell cycle, and the regulation of cell morphology, raising an important question for developing targeted methods to prevent cancer: which effects of TPA are crucial for carcinogenesis? To address this question, we studied TPA...
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