Article
MMP1, MMP9, and COX2 expressions in promonocytes are induced by breast cancer cells and correlate with collagen degradation, transformation-like morphological changes in MCF-10A acini, and tumor aggressiveness.
BioMed research international - 1 Jan 2013
Chimal-Ramírez G K, Espinoza-Sánchez N A, Utrera-Barillas D, Benítez-Bribiesca L, Velázquez J R, Arriaga-Pizano L A, Monroy-García A, Reyes-Maldonado E, Domínguez-López M L, Piña-Sánchez Patricia, Fuentes-Pananá E M
Abstract excerpt
Tumor-associated immune cells often lack immune effector activities, and instead they present protumoral functions. To understand how tumors promote this immunological switch, invasive and noninvasive breast cancer cell (BRC) lines were cocultured with a promonocytic cell line in a Matrigel-based 3D system. We hypothesized that if communication exists between tumor and immune cells, coculturing would result in...
Topics
- Acinar Cells
- Breast Neoplasms
- Cell Communication
- Cell Line, Tumor
- Cell Transformation, Neoplastic
- Coculture Techniques
- Collagen
- Cyclooxygenase 2
- Dinoprostone