Article
Pleiotropy of cancer susceptibility variants on the risk of non-Hodgkin lymphoma: the PAGE consortium.
PloS one - 1 Jan 2014
Lim Unhee, Kocarnik Jonathan M, Bush William S, Matise Tara C, Caberto Christian, Park Sungshim Lani, Carlson Christopher S, Deelman Ewa, Duggan David, Fesinmeyer Megan, Haiman Christopher A, Henderson Brian E, Hindorff Lucia A, Kolonel Laurence N, Peters Ulrike, Stram Daniel O, Tiirikainen Maarit, Wilkens Lynne R, Wu Chunyuan, Kooperberg Charles, Le Marchand Loïc
Abstract excerpt
BACKGROUND: Risk of non-Hodgkin lymphoma (NHL) is higher among individuals with a family history or a prior diagnosis of other cancers. Genome-wide association studies (GWAS) have suggested that some genetic susceptibility variants are associated with multiple complex traits (pleiotropy). OBJECTIVE: We investigated whether common risk variants identified in cancer GWAS may also increase the risk of developing NHL...
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