Article
Mechanistic study on the nuclear modifier gene MSS1 mutation suppressing neomycin sensitivity of the mitochondrial 15S rRNA C1477G mutation in Saccharomyces cerevisiae.
PloS one - 1 Jan 2014
Zhou Qiyin, Wang Wei, He Xiangyu, Zhu Xiaoyu, Shen Yaoyao, Yu Zhe, Wang Xuexiang, Qi Xuchen, Zhang Xuan, Fan Mingjie, Dai Yu, Yang Shuxu, Yan Qingfeng
Abstract excerpt
The phenotypic manifestation of mitochondrial DNA (mtDNA) mutations can be modulated by nuclear genes and environmental factors. However, neither the interaction among these factors nor their underlying mechanisms are well understood. The yeast Saccharomyces cerevisiae mtDNA 15S rRNA C1477G mutation (PR) corresponds to the human 12S rRNA A1555G mutation. Here we report that a nuclear modifier gene mss1 mutation...
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