Article
Activating the expression of human K-rasG12D stimulates oncogenic transformation in transgenic goat fetal fibroblast cells.
PloS one - 1 Jan 2014
Gong Jianhua, Wang Zhongde, Polejaeva Irina, Salgia Ravi, Kao Chien-Min, Chen Chin-Tu, Chen Guangchun, Chen Liaohai
Abstract excerpt
Humane use of preclinical large animal cancer models plays a critical role in understanding cancer biology and developing therapeutic treatments. Among the large animal candidates, goats have great potentials as sustainable sources for large animal cancer model development. Goats are easier to handle and cheaper to raise. The genome of the goats has been sequenced recently. It has been known that goats develop...
Topics
- Animals
- Animals, Genetically Modified
- Carcinogenesis
- Cell Transformation, Neoplastic
- Fetus
- Fibroblasts
- Genetic Vectors
- Goats
- Green Fluorescent Proteins
- Herpesvirus 1, Human
- Humans
- Integrases
- Mice, Nude