Article

Transgenic goats producing an improved version of cetuximab in milk

2020-06-07

Abstract excerpt

<h4>ABSTRACT</h4> Therapeutic monoclonal antibodies (mAbs) represent one of the most important classes of pharmaceutical proteins to treat human diseases. Most are produced in cultured mammalian cells which is expensive, limiting their availability. Goats, striking a good balance between a relatively short generation time and copious milk yield, present an alternative platform for the cost-effective, flexible, la...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 69ff0272-c380-5ee7-b503-e45764e28385
DOI: 10.1101/2020.06.05.137463

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transgenic goats producing an improved version of cetuximab in milkDOI 10.1101/2020.06.05.137463Read

Cetuximab produced from a goat mammary gland expression system is equally efficacious as innovator cetuximab in model systems of cancerSemantic proximity Read

Discovery and bio‐optimization of human antibody therapeutics using the XenoMouse® transgenic mouse platformSemantic proximity Read

Generation and GMP scale-up of human CAR-T cells using non-viral Sleeping Beauty transposons for B cell malignancesSemantic proximity Read

Antibody discovery ex vivo accelerated by the LacO/LacI regulatory network.Semantic proximity Read

Recent advances using FcRn overexpression in transgenic animals to overcome impediments of standard antibody technologies to improve the generation of specific antibodiesSemantic proximity Read

Transgenic Mouse Strains as Platforms for the Successful Discovery and Development of Human Therapeutic Monoclonal AntibodiesSemantic proximity Read

Heavy chain-only antibodies with a stabilized human VH in transgenic chickens for therapeutic antibody discoverySemantic proximity Read

Retrospective analysis of the preparation and application of immunotherapy in cancer treatment (Review)Semantic proximity Read

Production of Recombinant Human EGFR CR2 Domain and Generation of Monoclonal Antibodies Discriminating The R and K Variants.Semantic proximity Read

Chickens with humanized immunoglobulin genes generate antibodies with high affinity and broad epitope coverage to conserved targetsSemantic proximity Read

A precisely humanized FCRN transgenic mouse for preclinical pharmacokinetics studiesSemantic proximity Read

Zero-Shot Design of a Biobetter Cetuximab: Enhanced EGFR Affinity with Preserved DevelopabilitySemantic proximity Read