Article
Inflammatory cascades mediate synapse elimination in spinal cord compression.
Journal of neuroinflammation - 4 Mar 2014
Takano Morito, Kawabata Soya, Komaki Yuji, Shibata Shinsuke, Hikishima Keigo, Toyama Yoshiaki, Okano Hideyuki, Nakamura Masaya
Abstract excerpt
BACKGROUND: Cervical compressive myelopathy (CCM) is caused by chronic spinal cord compression due to spondylosis, a degenerative disc disease, and ossification of the ligaments. Tip-toe walking Yoshimura (twy) mice are reported to be an ideal animal model for CCM-related neuronal dysfunction, because they develop spontaneous spinal cord compression without any artificial manipulation. Previous histological...
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