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Article

The influence of ApoE4 on the clinical outcomes and pathophysiology of degenerative cervical myelopathy.

JCI insight - 9 Aug 2021

Desimone Alexa, Hong James, Brockie Sydney T, Yu Wenru, Laliberte Alex M, Fehlings Michael G

Abstract excerpt

Degenerative cervical myelopathy (DCM) is the most common cause of nontraumatic spinal cord injury in adults worldwide. Surgical decompression is generally effective in improving neurological outcomes and halting progression of myelopathic deterioration. However, a subset of patients experience suboptimal neurological outcomes. Given the emerging evidence that apolipoprotein E4 (ApoE4) allelic status influences...

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Identifiers

PMID: 34369386
DOI: 10.1172/jci.insight.149227
PMCID: PMC8410082

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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