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Article

DNA Damage and Its Cellular Response in Mother and Fetus Exposed to Hyperglycemic Environment

1 Jan 2014

Abstract excerpt

The increased production of reactive oxygen species (ROS) plays a key role in pathogenesis of diabetic complications. ROS are generated by exogenous and endogenous factors such as during hyperglycemia. When ROS production exceeds the detoxification and scavenging capacity of the cell, oxidative stress ensues. Oxidative stress induces DNA damage and when DNA damage exceeds the cellular capacity to repair it, the...

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PMID: 25197655
DOI: 10.1155/2014/676758

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