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Article

Long non‑coding RNA NONHSAT143692.2 is involved in oxidative DNA damage repair in the lens by regulating the miR‑4728‑5p/OGG1 axis.

International journal of molecular medicine - 1 Nov 2020

Zhou Tianqiu, Zhang Junfang, Qin Bai, Xu Hui, Zhang Shuqiang, Guan Huaijin

Abstract excerpt

Age‑related cataract (ARC) is the leading cause of blindness worldwide. Oxidative DNA damage is a biochemical feature of ARC pathogenesis. The present study investigated the role of long non‑coding RNAs in the DNA repair of oxidative damage, partially the regulation of the DNA repair gene, 8‑oxoguanine DNA glycosylase (OGG1), in lens affected by ARC. The ogg1 mutant zebrafish model was constructed to verify the...

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Identifiers

PMID: 33000245
DOI: 10.3892/ijmm.2020.4707
PMCID: PMC7521474

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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