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Article

Genes Associated with SLE Are Targets of Recent Positive Selection

1 Jan 2014

Abstract excerpt

The reasons for the ethnic disparities in the prevalence of systemic lupus erythematosus (SLE) and the relative high frequency of SLE risk alleles in the population are not fully understood. Population genetic factors such as natural selection alter allele frequencies over generations and may help explain the persistence of such common risk variants in the population and the differential risk of SLE. In order to...

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PMID: 24587899
DOI: 10.1155/2014/203435

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