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Article

Oncogenic H-Ras up-regulates acid β-hexosaminidase by a mechanism dependent on the autophagy regulator TFEB.

PloS one - 1 Jan 2014

Urbanelli Lorena, Magini Alessandro, Ercolani Luisa, Sagini Krizia, Polchi Alice, Tancini Brunella, Brozzi Alessandro, Armeni Tatiana, Principato Giovanni, Emiliani Carla

Abstract excerpt

The expression of constitutively active H-RasV12 oncogene has been described to induce proliferative arrest and premature senescence in many cell models. There are a number of studies indicating an association between senescence and lysosomal enzyme alterations, e.g. lysosomal β-galactosidase is the most widely used biomarker to detect senescence in cultured cells and we previously reported that H-RasV12...

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Share to Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Share to beta-N-Acetylhexosaminidases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24586816
DOI: 10.1371/journal.pone.0089485
PMCID: PMC3933543

Genes

TFEB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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