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Article

Estrogen receptor alpha inhibits senescence-like phenotype and facilitates transformation induced by oncogenic ras in human mammary epithelial cells.

Oncotarget - 28 Jun 2016

Liu Zhao, Wang Long, Yang Junhua, Bandyopadhyay Abhik, Kaklamani Virginia, Wang Shui, Sun Lu-Zhe

Abstract excerpt

Exposure to estrogen has long been associated with an increased risk of developing breast cancer. However, how estrogen signaling promotes breast carcinogenesis remains elusive. Senescence is known as an important protective response to oncogenic events. We aimed to elucidate the role of estrogen receptor alpha (ERα) on senescence in transformed human mammary epithelial cells and breast cancer cells. Our results...

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Identifiers

PMID: 27259243
DOI: 10.18632/oncotarget.9772
PMCID: PMC5129916

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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