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Article

Ras-related tumorigenesis is suppressed by BNIP3-mediated autophagy through inhibition of cell proliferation.

Neoplasia (New York, N.Y.) - 1 Dec 2011

Wu Shan-Ying, Lan Sheng-Hui, Cheng Da-En, Chen Wei-Kai, Shen Cheng-Huang, Lee Ying-Ray, Zuchini Roberto, Liu Hsiao-Sheng

Abstract excerpt

Autophagy plays diverse roles in Ras-related tumorigenesis. H-ras(val12) induces autophagy through multiple signaling pathways including Raf-1/ERK pathway, and various ERK downstream molecules of autophagy have been reported. In this study, Bcl-2/adenovirus E1B 19-kDa-interacting protein 3 (BNIP3) is identified as a downstream transducer of the Ras/Raf/ERK signaling pathway to induce autophagy. BNIP3 was...

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Identifiers

PMID: 22241963
DOI: 10.1593/neo.11888
PMCID: PMC3257192

Genes

BNIP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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