Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural and functional analysis of the costimulatory receptor programmed death-1.

Immunity - 1 Mar 2004

Zhang Xuewu, Schwartz Jean-Claude D, Guo Xiaoling, Bhatia Sumeena, Cao Erhu, Lorenz Michael, Cammer Michael, Chen Lieping, Zhang Zhong-Yin, Edidin Michael A, Nathenson Stanley G, Almo Steven C

Abstract excerpt

PD-1, a member of the CD28/CTLA-4/ICOS costimulatory receptor family, delivers negative signals that have profound effects on T and B cell immunity. The 2.0 A crystal structure of the extracellular domain of murine PD-1 reveals an Ig V-type topology with overall similarity to the CTLA-4 monomer; however, there are notable differences in regions relevant to function. Our structural and biophysical data show that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, Differentiation
Share to B7-1 Antigen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to B7-H1 Antigen

Share to Blood Proteins

Share to CTLA-4 Antigen

Share to Immunoglobulin Variable Region

Share to Programmed Cell Death 1 Receptor

Share to Receptors, Immunologic

Source

Identifiers

PMID: 15030777
DOI: 10.1016/s1074-7613(04)00051-2

Genes

ICOS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural and functional analysis of the costimulatory receptor programmed death-1.PMID 15030777Read ↗

Crystal structure of the complex between programmed death-1 (PD-1) and its ligand PD-L2.Semantic proximity Read ↗

Structural insight into T cell coinhibition by PD-1H (VISTA)Semantic proximity Read ↗

Considering B7-CD28 as a family through sequence and structureSemantic proximity Read ↗

The Role of the CD28 Family Receptors in T-Cell ImmunomodulationSemantic proximity Read ↗

Recent Findings in the Regulation of Programmed Death Ligand 1 ExpressionSemantic proximity Read ↗

The CD28 family: a T-cell rheostat for therapeutic control of T-cell activationSemantic proximity Read ↗

Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses.Semantic proximity Read ↗

Genetic and Epigenetic Regulation of PD-1 ExpressionSemantic proximity Read ↗

Identification of the functional PD-L1 interface region responsible for PD-1 binding and initiation of PD-1 signaling.Semantic proximity Read ↗

The B7 family of immune-regulatory ligands.Semantic proximity Read ↗

Traversing through the Dynamic Protein–Protein Interaction Landscape and Conformational Plasticity of PD-1 for Small-Molecule DiscoverySemantic proximity Read ↗

ILT7 activation and plasmacytoid dendritic cell response are governed by BST2 determinants that are structurally-distinctSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.