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Article

Preservation of general intelligence following traumatic brain injury: contributions of the Met66 brain-derived neurotrophic factor.

PloS one - 1 Jan 2014

Barbey Aron K, Colom Roberto, Paul Erick, Forbes Chad, Krueger Frank, Goldman David, Grafman Jordan

Abstract excerpt

Brain-derived neurotrophic factor (BDNF) promotes survival and synaptic plasticity in the human brain. The Val66Met polymorphism of the BDNF gene interferes with intracellular trafficking, packaging, and regulated secretion of this neurotrophin. The human prefrontal cortex (PFC) shows lifelong neuroplastic adaption implicating the Val66Met BDNF polymorphism in the recovery of higher-order executive functions...

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Identifiers

PMID: 24586380
DOI: 10.1371/journal.pone.0088733
PMCID: PMC3935849

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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