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Article

BDNF genotype associated with changes in cortical thickness, severity of symptoms, and cognitive impairments in mild traumatic brain injury.

Molecular brain - 14 Oct 2025

Shi Lei, Pan Yizhen, Yuan Jie, Zhang Jue, Lee Zhiqi, Li Xuan, Zhang Haonan, Zhang Xiang, Wu Tingting, Ding Jierui, Liu Tao, Guo Nengrui, Wang Zhuonan, Bai Lijun

Abstract excerpt

OBJECTIVE: Brain-derived neurotrophic factor (BDNF) is a critical blood protein for brain function; however, its genotypic influence on clinical outcomes and brain structure following mild traumatic brain injury (mTBI) remains unclear. This study investigated the relationship between BDNF polymorphisms and cognitive impairment, symptom severity, and cortical structural injury in mTBI patients. MATERIALS AND...

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Identifiers

PMID: 41088133
DOI: 10.1186/s13041-025-01239-1
PMCID: PMC12522302

Genes

BDNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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