Article
Brain-derived neurotrophic factor (Val66Met) polymorphism does not influence recovery from a post-traumatic vegetative state: a blinded retrospective multi-centric study.
Journal of neurotrauma - 20 Jul 2012
Bagnato Sergio, Minafra Luigi, Bravatà Valentina, Boccagni Cristina, Sant'angelo Antonino, Castiglione Alberto, Andriolo Maria, Lucca Lucia Francesca, De Tanti Antonio, Pistarini Caterina, Formisano Rita, Dolce Giuliano, Gelfi Cecilia, Galardi Giuseppe
Abstract excerpt
Brain-derived neurotrophic factor (BDNF) is a neurotrophin that influences neuronal plasticity throughout life. Emergence from a vegetative state (VS) after a traumatic brain injury (TBI) implies that the brain undergoes plastic changes. A common polymorphism in the BDNF gene--BDNF Val66Met (referred to herein as BDNF(Met))--impairs cognitive function in healthy subjects. The aim of this study was to determine...
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