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Article

Globular adiponectin induces a pro-inflammatory response in human astrocytic cells.

Biochemical and biophysical research communications - 28 Mar 2014

Wan Zhongxiao, Mah Dorrian, Simtchouk Svetlana, Klegeris Andis, Little Jonathan P

Abstract excerpt

Neuroinflammation, mediated in part by activated brain astrocytes, plays a critical role in the development of neurodegenerative disorders, including Alzheimer's disease (AD). Adiponectin is the most abundant adipokine secreted from adipose tissue and has been reported to exert both anti- and pro-inflammatory effects in peripheral tissues; however, the effects of adiponectin on astrocytes remain unknown. Shifts...

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PMID: 24582565
DOI: 10.1016/j.bbrc.2014.02.077

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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