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Pro-inflammatory cytokines induce the transcription factors C/EBP? and C/EBP? in astrocytes

1 Jan 2000

Abstract excerpt

The transcription factors CCAAT/enhancer binding protein (C/EBP)-beta and -delta are key regulators for the expression of the acute phase genes in the liver, such as complement component C3 and antichymotrypsin. In the brain, these acute phase proteins are produced in response to pro-inflammatory cytokines by the reactive astrocytes, in particular those surrounding the amyloid plaques of Alzheimer's disease...

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PMID: 10594926
DOI: 10.1002/(sici)1098-1136(20000101)29:1<91::aid-glia9>3.0.co;2-i

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