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Article

Flavaglines target primitive leukemia cells and enhance anti-leukemia drug activity.

Leukemia - 1 Oct 2014

Callahan K P, Minhajuddin M, Corbett C, Lagadinou E D, Rossi R M, Grose V, Balys M M, Pan L, Jacob S, Frontier A, Grever M R, Lucas D M, Kinghorn A D, Liesveld J L, Becker M W, Jordan C T

Abstract excerpt

Identification of agents that target human leukemia stem cells is an important consideration for the development of new therapies. The present study demonstrates that rocaglamide and silvestrol, closely related natural products from the flavagline class of compounds, are able to preferentially kill functionally defined leukemia stem cells, while sparing normal stem and progenitor cells. In addition to efficacy as...

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Identifiers

PMID: 24577530
DOI: 10.1038/leu.2014.93
PMCID: PMC4148474

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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