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Article

Novel flavagline‐like compounds with potent Fli‐1 inhibitory activity suppress diverse types of leukemia

2 Nov 2018

Abstract excerpt

E26 transformation-specific (ETS) gene family contains a common DNA-binding domain, the ETS domain, responsible for sequence-specific DNA recognition on target promoters. The Fli-1 oncogene, a member of ETS gene family, plays a critical role in hematopoiesis and is overexpressed in diverse hematological malignancies. This ETS transcription factor regulates genes controlling several hallmarks of cancer and thus...

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PMID: 30387554
DOI: 10.1111/febs.14690

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