Article
Pleckstrin homology domain containing 6 protein (PLEKHA6) polymorphisms are associated with psychopathology and response to treatment in schizophrenic patients.
Progress in neuro-psychopharmacology & biological psychiatry - 3 Jun 2014
Spellmann Ilja, Rujescu Dan, Musil Richard, Meyerwas Sebastian, Giegling Ina, Genius Just, Zill Peter, Dehning Sandra, Cerovecki Anja, Seemüller Florian, Schennach Rebecca, Hartmann Annette M, Schäfer Martin, Müller Norbert, Möller Hans-Jürgen, Riedel Michael
Abstract excerpt
Pleckstrin homology domain (PH domain) comprises approximately 120 amino acids and is integrated in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton. This domain can bind phosphatidylinositol (3,4,5)-triphosphate and phosphatidylinositol (4,5)-biphosphate and proteins such as the βγ-subunits of heterotrimeric G proteins and protein kinase C. Associations with...
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