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Article

The PDLIM5 gene and lithium prophylaxis: an association and gene expression analysis in Sardinian patients with bipolar disorder.

Pharmacological research - 1 May 2008

Squassina Alessio, Congiu Donatella, Manconi Francesca, Manchia Mirko, Chillotti Caterina, Lampus Simona, Severino Giovanni, Zompo Maria Del

Abstract excerpt

A number of studies support the notion that lithium interacts with the protein kinase C (PKC) pathway, an important mediator of several intracellular responses to neurotransmitter signaling. PDLIM5 (PDZ and LIM domain 5; LIM) is an adaptor protein that selectively binds the isozyme PKC(epsilon) to N-type Ca(2+) channels in neurons. We tested for an association between three single nucleotide polymorphisms (SNPs)...

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Source

Identifiers

PMID: 18456508
DOI: 10.1016/j.phrs.2008.03.011

Genes

PDLIM5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The PDLIM5 gene and lithium prophylaxis: an association and gene expression analysis in Sardinian patients with bipolar disorder.PMID 18456508Read ↗

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Gene expression and association analysis of LIM (PDLIM5) in major depressionSemantic proximity Read ↗

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A polymorphism in the PDLIM5 gene associated with gene expression and schizophrenia.Semantic proximity Read ↗

PDLIM5 and susceptibility to bipolar disorder: a family-based association study and meta-analysis.Semantic proximity Read ↗

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