Article
A case-control association study of the PDLIM5 gene and bipolar disorder in a Sardinian sample.
Psychiatric genetics - 1 Jun 2008
Squassina Alessio, Manchia Mirko, Manconi Francesca, Piccardi Mariapaola, Ardau Raffaella, Chillotti Caterina, Severino Giovanni, Del Zompo Maria
Abstract excerpt
OBJECTIVES: PDLIM5 (ENH, LIM protein) [Postsynaptic Density-95/discs large/Zone occludens-1 (PDZ) and Lin-11, Isl-1, Mec-3 (LIM) domain 5;] is an adaptor protein that selectively binds protein kinase C-epsilon (PKC epsilon) to N-type Ca channels in brain neurons. As it has been suggested that alterations in protein kinase C activity might be involved in the pathophysiology of bipolar disorder (BD), PDLIM5 might...
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