Article
A high-resolution melting protocol for rapid and accurate differential diagnosis of thyroid nodules.
The Journal of molecular diagnostics : JMD - 1 Sept 2012
Mancini Irene, Pinzani Pamela, Pupilli Cinzia, Petrone Luisa, De Feo Maria Laura, Bencini Lapo, Pazzagli Mario, Forti Gianni, Orlando Claudio
Abstract excerpt
A large majority of thyroid nodules are benign, and only 5% have malignant features on cytological examination. Unfortunately, fine-needle aspiration is inconclusive in approximately 30% of all thyroid biopsies, because the cytological features are indeterminate (suspicious for malignancy but not completely diagnostic or nondiagnostic). Wide panels of somatic mutations have been identified in thyroid cancers, and...
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